The Daiichi Sankyo Group of companies has established global occupational health and safety (OHS) measures and targets for EHS (Environment, Health and Safety). The EHS Management Committee is headed by the Head of EHS management (Takashi Fukuoka, Executive Officer, Head of Global Corporate Strategy). 
The EHS Management Committee has set numerical targets of “occupational accident frequency rate” and “the number of people who took 30 days or more of non-occupational injury or illness leave” as KPIs for OHS activities. Accordingly, the committee office collects and compiles data of all DS Group companies every fiscal year. 
The EHS Management Committee also promotes health and safety measures based on the medium-term policy for health and safety management agreed upon by the group companies in Japan and the labor unions within Japan. 
As one of the Group’s global health measures, a Health Promotion Plan is established, operated, and evaluated every fiscal year in Daiichi Sankyo Group of companies sites globally. As one example of a global safety measure, Occupational Health and Safety Management System (OHSMS) based on ISO45001 has been implemented in all Daiichi Sankyo Group of companies sites globally since April 2021. In addition, e-learning regarding OHS was conducted in all Daiichi Sankyo Group of companies in FY2021.
Summary of OHSMS:

• Understanding the organization and its context
• Leadership and commitment
• Formulate policy
• Consultation and participation of workers
• Determine legal and other requirements
• Hazard identification and risk assessment
• Plan action to address risks in order of assessment points
• Implement risk reducing actions
• Emergency preparedness and response
• Performance evaluation
• Continual improvement

DS Health and Productivity Management Promotion Structure

Daiichi Sankyo Health & Safety Strategy

In Japan, at the moment, Daiichi Sankyo is working with the Health Insurance Association and labor union to enhance the environment where employees can actively maintain and improve their health by accurately understanding their own physical condition. We have set performance indicators (see figure below) and goals to reinforce health guidance and employee awareness. (See “Voice” below.)

Evaluation Index	Fiscal 2017 Actual	Fiscal 2019 Target	Fiscal 2020 Target
Ratio of Smokers	19.4%	16%	15%
Ratio of Implementing Health-Related Events at Each Workplace	28.1%	70%	80%
Self-Care Initiative Rate*1	70.6%	80%	80%
Ratio of Medical Examination	53.9%	70%	80%
Ratio of Conducting Specific Health Guidance	36.0%	40%	50%
Ratio of Individuals with Abnormal Findings Receiving Checkups at a Medical Institution*2	86.7%	100%	100%

• *1The rate of self-care initiatives taken by people designated as having high levels of stress as a result of stress checks
• *2The ratio of employees that have received checkups at a medical institution after being instructed to do so in regular checkups

As part of our initiatives for safety in Japan, we collaborate with occupational physicians to develop safety management activities centered around the prevention of occupational accidents.
In addition, we regularly measure the temperature, humidity, noise, luminous intensity, and other aspects, constantly checking that there are no issues so that all employees can carry out their duties in a comfortable work environment.
In addition to the above, we carry out inspections on the air concentrations of chemical substances and other materials at plants and research facilities in Japan that handle these materials, and we conduct special health checkups for employees that work at these locations.
Each operating site holds occupational health and safety committee meetings along with the labor union, working to share information on the status of work hour management, the occurrence of occupational accidents, and the health and safety of workplaces. Collaborative workplace inspections are also held on a regular basis.

Systems and initiatives for supporting occupational health and safety in Japan

Details Regarding Systems	Initiatives
Regular Health Checkups	All employees at Group companies in Japan undergo regular health checkups based on uniform standards. We cooperate with the Daiichi Sankyo Group Health Insurance Association to provide these employees suffering from or at risk of metabolic syndrome with nutrition and other guidance for improving their lifestyles from a health standpoint.
Excessive Overtime Countermeasures	Consultations with physicians are provided for employees in Japan working extra hours. Those requiring additional care are offered personalized guidance that is coordinated between their supervisor and an occupational physician.
Medical Examination Program	For the purpose of encouraging all employees at Group companies in Japan to receive medical examinations, we cooperate with the Daiichi Sankyo Group Health Insurance Association and offer time-off for these employees undergoing examinations. Dependents of these employees are also encouraged to receive examinations.
Mental Health Support	We conduct stress checks, and individually conduct follow-up on Japan Group companies employees generally and assigned to organizations with high stress levels. Training is conducted regarding self-care*1 and line-care*2, among other initiatives to prevent mental health issues among these employees. Contracts are concluded with external mental health counseling firms that enable these employees to receive counseling at any time.
Return-to-Work Assistance	We operate a return-to-work assistance program with the aim of achieving a smooth return to work after medical leave following injury or illness, as well as with the aim of preventing recurrence of illness. Based on this program, we assess whether Japan Group company employees in poor health are ready to return to work and conduct follow-up during and after their return to work while working with occupational physicians and occupational healthcare staff.
Dealing with Cancer	With the objective of helping Japan Group company employees balance work and treatment, we have introduced a medical recovery leave system for those undergoing out-patient cancer treatment through which leave can be acquired in half- or full-day increments. Japan Group companies have also constructed guidebooks on living with cancer that are offered to employees to provide them with basic knowledge regarding cancer and information on the Company's support systems for helping them work with peace of mind as they battle cancer. Additionally, we have introduced a system where these Group employees can acquire leave in half- or full-day increments for treating diseases other than cancer.
Internal Health Website	We have established a website featuring information about health on the Company intranet. This website presents these Group employees with information on the state of progress in promoting health management as well as applicable Company systems along with a wide variety of other aspects related to health.
Health Databank	The Health Databank is equipped with centralized data management functions for medical checkup results. Employees of the Japan Group companies can access their individual results, along with self-care functions, including stress checks and fatigue assessment tests.
Health and Safety Training	[Chemical safety education] Frequency: Twice a year Participants: Researchers on synthetics Details: Conducting education and training with the aim of thoroughly promoting the appropriate management of reagents according to laws and regulations, the prevention of accidents, and adherence to chemical compliance [Animal testing]Frequency: About twice a year Participants: Researchers conducting animal experiments and breeding staff Details: Conducting education and training with the aim of thoroughly promoting the performance of animal testing appropriately and in accordance with animal testing laws and regulations, as well as animal welfare and occupational health and safety [Radioisotopes]Frequency: Initially and once a year Participants: Employees engaged in work involving radiation Details: Conducting the necessary education and training to prevent radiation hazards
Health Improvement Support	We are working with the Daiichi Sankyo Group Health Insurance Association to offer programs to help Group company employees in Japan adjust their lifestyles to realize healthier living, such as by walking for exercise, quitting smoking, or cutting back on alcohol. We also provide access to the KenCoM health management Internet service. We also plan and organize health-related events independently within each workplace.
Group Long-Term Disability Insurance System	To help mitigate the risk of losing one's livelihood, the Group Long-Term Disability Insurance System in Japan guarantees a fixed portion of income, possibly paid up to the retirement age, for eligible employees rendered incapable of working due to sickness or injury.

• *1Activities are aimed at letting employees gain a better understanding of stress and mental health to enable them to handle their own stress properly.
• *2Activities spearheaded by supervisors, who interact with their subordinates on a daily basis, include improving workplace environments to support good mental health and responding to consultations from subordinates.